7198/10 | Tocris Bioscience 7198/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7198/10

catalog :

7198/10

quantity :

10 mg (also 50 mg)

price :

229 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7198 - JHU 37160 C19H20ClFN4 CAS No. 2369979-68-8

product information

master code :

7198

SKU :

7198/10

product name :

JHU 37160

unit size :

10 mg (also 50 mg)

description :

High affinity and highly potent hM3Dq and hM4Di DREADD agonist; blood brain barrier penetrant

target :

DREADD Activators

category :

Small Molecules

purity :

98%

observed molecular weight :

358.85

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

JHU 37160 is a high affinity and highly potent activator of hM3Dq and hM4Di DREADDs (Ki values are 1.9 nM and 3.6 nM for hM3Dq and hM4Di in vitro , respectively; EC50 values are 0.2 nM and 18.5 nM for hM4Di and hM3Dq in vitro , respectively). Displays approximately 25-fold higher affinity for hM4Di compared to DREADD agonist 21 (Cat. No. 5548). Selectively displaces [3H]clozapine from DREADDs in vivo , but not from other clozapine binding sites. Inhibits locomotor activity in mice expressing hM3Dq and hM4Di in D1-expressing neurons, and increases hM3Dq-stimulated locomotion in rats expressing hM3Dq in TH-expressing neurons. Brain penetrant in mice, rats and non-human primates.

top caption :

High affinity and highly potent hM3Dq and hM4Di DREADD agonist; blood brain barrier penetrant

extended description :

High affinity and highly potent hM3Dq and hM4Di DREADD agonist; blood brain barrier penetrant

chemical name text :

8-Chloro-11-(4-ethylpiperazin-1-yl)-4-fluoro-5H-dibenzo[b,e][1,4]diazepine

formula :

C19H20ClFN4

formula text :

C19H20ClFN4

cas num :

2369979-68-8

USD :

229 USD

product details :

High affinity and highly potent hM3Dq and hM4Di DREADD agonist; blood brain barrier penetrant

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage