7197/10 | Tocris Bioscience 7197/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7197/10

catalog :

7197/10

quantity :

10 mg (also 50 mg)

price :

200 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7197 - JHU 37152 C19H20ClFN4 CAS No. 2369979-67-7

product information

master code :

7197

SKU :

7197/10

product name :

JHU 37152

unit size :

10 mg (also 50 mg)

description :

High affinity and highly potent hM3Dq and hM4Di DREADD agonist; blood brain barrier penetrant

target :

DREADD Activators

category :

Small Molecules

purity :

98%

observed molecular weight :

358.85

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

JHU 37152 is a high affinity and highly potent activator of hM3Dq and hM4Di DREADDs (Ki values are 1.8 nM and 8.7 nM for hM3Dq and hM4Di in vitro , respectively; EC50 values are 5 nM and 0.5 nM for hM3Dq and hM4Di in vitro , respectively). Selectively displaces [3H]clozapine from DREADDs in vivo , but not from other clozapine binding sites. Inhibits locomotor activity in mice expressing hM3Dq and hM4Di in D1-expressing neurons. Brain penetrant in mice, rats and non-human primates.

top caption :

High affinity and highly potent hM3Dq and hM4Di DREADD agonist; blood brain barrier penetrant

extended description :

High affinity and highly potent hM3Dq and hM4Di DREADD agonist; blood brain barrier penetrant

chemical name text :

8-Chloro-11-(4-ethylpiperazin-1-yl)-1-fluoro-5H-dibenzo[b,e][1,4]diazepine

formula :

C19H20ClFN4

formula text :

C19H20ClFN4

cas num :

2369979-67-7

USD :

200 USD

product details :

High affinity and highly potent hM3Dq and hM4Di DREADD agonist; blood brain barrier penetrant

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage