7196/50 | Tocris Bioscience 7196/50 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7196/50

catalog :

7196/50

quantity :

50 mg

price :

136 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Hong Brown L, Pruznak A, Frost R, Vary T, Lang C. Indinavir alters regulators of protein anabolism and catabolism in skeletal muscle. Am J Physiol Endocrinol Metab. 2005;289:E382-90 pubmed

image

image 1 :

Cat.No. 7196 - Indinavir sulfate C36H47N5O4.H2SO4 CAS No. 157810-81-6

product information

master code :

7196

SKU :

7196/50

product name :

Indinavir sulfate

unit size :

50 mg

description :

Potent and selective HIV-1 and HIV-2 protease inhibitor

target :

HIV Protease Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

711.88

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Indinavir sulfate is a potent and selective HIV protease inhibitor (Ki values are 0.52 and 3.3 nM for HIV-1 and HIV-2, respectively). Indinavir stops the spread of the HIV-infected MT4 lymphoid cells at concentrations of 25-50 nM. Indinavir disrupts the ERK1/2 and p38 MAPK pathways and reduces both the level of functional eIF4F complex and rpS6 phosphorylation, which leads to a decrease in protein synthesis in mouse myocytes. In silico docking models predict potential as an inhibitor of SARS-CoV-2 3CLpro.

top caption :

Potent and selective HIV-1 and HIV-2 protease inhibitor

extended description :

Potent and selective HIV-1 and HIV-2 protease inhibitor

chemical name text :

2,3,5-Trideoxy-N-[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]-5-[(2S)-2-[[(1,1-dimethylethyl)amino]carbonyl]-4-(3-pyridinylmethyl)-1-piperazinyl]-2-(phenylmethyl)-D-erythro-pentonamide sulfate

formula :

C36H47N5O4.H2SO4

formula text :

C36H47N5O4.H2SO4

cas num :

157810-81-6

USD :

136 USD

product details :

Potent and selective HIV-1 and HIV-2 protease inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage