7194/50 | Tocris Bioscience 7194/50 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7194/50

catalog :

7194/50

quantity :

50 mg

price :

61 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7194 - Erlotinib Hydrochloride C22H23N3O4.HCl CAS No. 183319-69-9

product information

master code :

7194

SKU :

7194/50

product name :

Erlotinib Hydrochloride

unit size :

50 mg

description :

Potent, reversible EGFR tyrosine kinase inhibitor

target :

EGF Receptor Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

429.9

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Erlotinib hydrochloride is a reversible, potent EGFR tyrosine kinase inhibitor (IC50 = 2 nM); it reduces EGFR autophosphorylation in intact tumor cells (IC50 = 20 nM). Erlotinib is selective for cell lines showing PC-9 and H3255 mutations (IC50 values are 7 and 12 nM, respectively, sparing wild-type and T790 mutant EGFR. Erlotinib shows antiproliferative effects in cancer cell lines in vitro and promotes differentiation of urothelial organoids. Orally bioavailable.

top caption :

Potent, reversible EGFR tyrosine kinase inhibitor

extended description :

Potent, reversible EGFR tyrosine kinase inhibitor

chemical name text :

N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride

formula :

C22H23N3O4.HCl

formula text :

C22H23N3O4.HCl

cas num :

183319-69-9

USD :

61 USD

product details :

Potent, reversible EGFR tyrosine kinase inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage