7193/10 | Tocris Bioscience 7193/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7193/10

catalog :

7193/10

quantity :

10 mg (also 50 mg)

price :

155 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Sheu S, Upadhyayula S, Dupuy V, Pang S, Deng F, Wan J, et al. A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility. Cell. 2022;185:3390-3407.e18 pubmed publisher

image

image 1 :

Cat.No. 7193 - Deschloroclozapine C18H20N4 CAS No. 1977-07-7

product information

master code :

7193

SKU :

7193/10

product name :

Deschloroclozapine

unit size :

10 mg (also 50 mg)

description :

High affinity and highly potent activator of hM3Dq and hM4Di DREADDs; rapidly blood brain barrier penetrant

target :

DREADD Activators

category :

Small Molecules

purity :

98%

observed molecular weight :

292.39

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Deschloroclozapine is a high affinity and highly potent activator of muscarinic DREADDs (Ki values are 6.3 nM for hM3Dq and 4.2 nM for hM4Di, in vitro ; EC50 values are 0.13 nM for hM3Dq and 0.081 nM for hM4Di, in vitro ). Derivative of clozapine (Cat. No. 0444). Exhibits 100-fold greater affinity for hM3Dq and hM4Di compared to clozapine N -oxide (CNO; Cat. No. 4936), and 50-fold greater affinity compared to DREADD agonist 21 (Cat. No. 5548). Displays low off-target receptor binding (Ki 100 nM at majority of GPCRs, ion channels and transporters tested). Displays rapid (approx. 10 minutes after i.p injection) binding and activation of hM3Dq and hM4Di in mice and non-human primates. Induces spatial memory deficits in non-human primates expressing hM4Di in the prefrontal cortex.

top caption :

High affinity and highly potent activator of hM3Dq and hM4Di DREADDs; rapidly blood brain barrier penetrant

extended description :

High affinity and highly potent activator of hM3Dq and hM4Di DREADDs; rapidly blood brain barrier penetrant

chemical name text :

11-(4-Methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine

formula :

C18H20N4

formula text :

C18H20N4

cas num :

7/7/77

USD :

155 USD

product details :

High affinity and highly potent activator of hM3Dq and hM4Di DREADDs; rapidly blood brain barrier penetrant

alt names :

DCZ

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage