7192/10 | Tocris Bioscience 7192/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7192/10

catalog :

7192/10

quantity :

10 mg (also 50 mg)

price :

245 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7192 - SMIP 004 C13H19NO CAS No. 143360-00-3

product information

master code :

7192

SKU :

7192/10

product name :

SMIP 004

unit size :

10 mg (also 50 mg)

description :

SKP2 (S-phase kinase-associated protein 2) inhibitor; upregulates p27 and arrests cell cycle in G1 phase

target :

Ubiquitin Ligase (E3) Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

205.3

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SMIP 004 is an SKP2 (S-phase kinase-associated protein 2) inhibitor. Upregulates p27 and activates the unfolded protein response (UPR) in LNCaP prostate cancer cells overexpressing SKP2. Also induces oxidative stress. Induces proteasomal degradation of cyclin D1 and acts as CDK2 inhibitor. Arrests cell cycle in G1 phase and induces apoptosis in prostate cancer cells, but not normal cells in vitro . Inhibits growth of breast and prostate cancer xenografts in mice. Also induces autophagy and reduces replication of MERS-CoV in VeroB4 cells.

top caption :

SKP2 (S-phase kinase-associated protein 2) inhibitor; upregulates p27 and arrests cell cycle in G1 phase

extended description :

SKP2 (S-phase kinase-associated protein 2) inhibitor; upregulates p27 and arrests cell cycle in G1 phase

chemical name text :

N-(4-Butyl-2-methylphenyl)acetamide

formula :

C13H19NO

formula text :

C13H19NO

cas num :

143360-00-3

USD :

245 USD

product details :

SKP2 (S-phase kinase-associated protein 2) inhibitor; upregulates p27 and arrests cell cycle in G1 phase

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage