7188/10 | Tocris Bioscience 7188/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7188/10

catalog :

7188/10

quantity :

10 mg (also 50 mg)

price :

158 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7188 - Carfilzomib C40H57N5O7 CAS No. 868540-17-4

product information

master code :

7188

SKU :

7188/10

product name :

Carfilzomib

unit size :

10 mg (also 50 mg)

description :

Potent irreversible proteasome inhibitor; active in vivo

target :

Proteasome Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

719.92

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Carfilzomib is a potent irreversible proteasome inhibitor. Preferentially inhibits the chymotrypsin-like 5 subunit of the constitutive 20S proteasome (IC50 = 5.2 nM) and the 5i subunit of the immunoproteasome 20Si (LMP7; IC50 = 14 nM) in vitro with minimal cross-reactivity to other proteases. Exhibits little or no effect on PGPH and T-L activities. Activates prosurvival autophagy and induces cell apoptosis. Acts synergistically with dexamethasone (Cat. No. 1126). Suppresses tumor growth in an in vivo xenograft model. Decreases bone resorption and enhances bone formation in non-tumor bearing mice.

top caption :

Potent irreversible proteasome inhibitor; active in vivo

extended description :

Potent irreversible proteasome inhibitor; active in vivo

chemical name text :

( S)- -[[2-(4-Morpholinyl)acetyl]amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-L-phenylalaninamide

formula :

C40H57N5O7

formula text :

C40H57N5O7

cas num :

868540-17-4

USD :

158 USD

product details :

Potent irreversible proteasome inhibitor; active in vivo

alt names :

PR-171

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage