7183/10 | Tocris Bioscience 7183/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7183/10

catalog :

7183/10

quantity :

10 mg (also 50 mg)

price :

227 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

UNC 6934 CAS No. 2561494-77-5 Antagonizes PWWP1 interaction with nucleosomal H3K36me2, alters NSD2 nucleolar localization.

product information

master code :

7183

SKU :

7183/10

product name :

UNC 6934

unit size :

10 mg (also 50 mg)

description :

Antagonizes PWWP1 interaction with nucleosomal H3K36me2, alters NSD2 nucleolar localization

target :

Lysine Methyltransferase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

443.46

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

UNC 6934 binds to the N-terminal proline-tryptophan-tryptophan-proline (PWWP) domain of nuclear receptor-binding SET domain-containing 2 (NSD2). UNC 6934 inhibits PWWP1 interaction with nucleosomal H3K36me2 (IC50 = 104 nM) by occupying the canonical H3K36me2-binding pocket of PWWP1. It selectively binds endogenous NSD2 in cells and causes accumulation of endogenous NSD2 in the nucleolus.

top caption :

Antagonizes PWWP1 interaction with nucleosomal H3K36me2, alters NSD2 nucleolar localization

extended description :

Antagonizes PWWP1 interaction with nucleosomal H3K36me2, alters NSD2 nucleolar localization

chemical name text :

N-Cyclopropyl-3,4-dihydro-3-oxo-N-[[4-[(4-pyrimidinylamino)carbonyl]phenyl]methyl]-2H-1,4-benzoxazine-7-carboxamide

formula :

C24H21N5O4

formula text :

C24H21N5O4

cas num :

2561494-77-5

USD :

227 USD

product details :

Antagonizes PWWP1 interaction with nucleosomal H3K36me2, alters NSD2 nucleolar localization

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage