NR 7h | Tocris Bioscience 7177 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

NR 7h

catalog :

7177

quantity :

5 mg

price :

369 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7177 - NR 7h C48H50BrF2N9O8

product information

brand :

Tocris

master code :

7177

SKU :

7177/5

product name :

NR 7h

description :

Potent and selective p38 and p38 degrader; active in vivo

target :

Active Degraders

category :

Small Molecules

unit size :

5 mg

purity :

97%

observed molecular weight :

998.87

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective p38 and p38 degrader (DC50 50 nM). Displays no significant degradation of p38 , p38 , JNK1/2 or ERK1/2. Inhibits phosphorylation of MK2 in UV-treated cancer cells and LPS-stimulated bone marrow-derived macrophages (BMDM). Exhibits similar effect to p38 gene knockout in BBL358 cells. Active in vivo .

catalog number base :

7177

product keywords :

NR7h protac PROTACs p38alpha alfa p38a p38beta p38b MAPK Proteolysis targeted chimeras in vivo active active degraders degrades targeted protein degradation tpd Active Degraders p38 7177, target protein knockdown, PROTAC, SNIPER

extended description :

Potent and selective p38 and p38 degrader; active in vivo

chemical name text :

3-(3-Bromo-4-((2,4-difluorobenzyl)oxy)-6-methyl-2-oxopyridin-1(2H)-yl)-N-(4-(1-(4-((4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butyl)amino)-4-oxobutyl)-1H-1,2,3-triazol-4-yl)butyl)-4-methylbenzamide

formula :

C 48 H 50 BrF 2 N 9 O 8

formula text :

C48H50BrF2N9O8

2020 USD :

369

2021 USD :

369 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage