7163/10 | Tocris Bioscience 7163/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7163/10

catalog :

7163/10

quantity :

10 mg (also 50 mg)

price :

416 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Windham I, Powers A, Ragusa J, Wallace E, Zanellati M, Williams V, et al. APOE traffics to astrocyte lipid droplets and modulates triglyceride saturation and droplet size. J Cell Biol. 2024;223: pubmed publisher
Fujimoto K, Kameda Y, Nagano Y, Deguchi S, Yamamoto T, Krol R, et al. SARS-CoV-2-induced disruption of a vascular bed in a microphysiological system caused by type-I interferon from bronchial organoids. Lab Chip. 2024;24:3863-3879 pubmed publisher

image

image 1 :

Cat.No. 7163 - Chroman 1 C24H28N4O4.2HCl

product information

master code :

7163

SKU :

7163/10

product name :

Chroman 1

unit size :

10 mg (also 50 mg)

description :

Highly potent and selective ROCK 2 inhibitor; improves cell survival after cryogenesis

target :

Rho-kinase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

509.43

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Chroman 1 is a highly potent and selective ROCK2 (Rho-kinase) inhibitor (IC50 values are 1 and 52 pM at ROCK2 and ROCK1, respectively). Chroman 1 exhibits 2000-fold selectivity for ROCK2 over a range of related kinases including MRCK, PKA, and AKT1 (IC50 values are 150, 20000, and 20000 nM, respectively). Chroman 1 promotes survival of pluripotent stem cells (PSCs) in culture when used in combination with Emricasan (Cat. No. 7310), Polyamine Supplement x1000 (lyophilized) (Cat. No. 7739), and trans-ISRIB (Cat. No. 5284), a combination known as CEPT. When used as part of the CEPT cocktail, Chroman 1 also improves survival of differentiated cells following cryopreservation with cardiomyocyte cell survival increasing by 36% and motor neuron survival improving by 63% compared with DMSO controls.

top caption :

Highly potent and selective ROCK 2 inhibitor; improves cell survival after cryogenesis

extended description :

Highly potent and selective ROCK 2 inhibitor; improves cell survival after cryogenesis

chemical name text :

(3S)-N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-3,4-dihydro-6-methoxy-2H-1-benzopyran-3-carboxamide dihydrochloride

formula :

C24H28N4O4.2HCl

formula text :

C24H28N4O4.2HCl

USD :

416 USD

product details :

Highly potent and selective ROCK 2 inhibitor; improves cell survival after cryogenesis

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage