DD 03-171 | Tocris Bioscience 7160 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

DD 03-171

catalog :

7160

quantity :

5 mg

price :

369 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7160 - DD 03-171 C55H62N10O8 CAS No. 2366132-45-6

product information

brand :

Tocris

master code :

7160

SKU :

7160/5

product name :

DD 03-171

description :

Potent and selective BTK Degrader

target :

Active Degraders

category :

Small Molecules

unit size :

5 mg

purity :

98%

observed molecular weight :

991.16

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective BTK Degrader (IC50 = 5.1 nM); degrades BTK in a proteasome- and CRBN-dependent manner. Suppresses BTK signaling and proliferation in mantle cell lymphoma (MCL) cells by degrading BTK, IKFZ1, and IKFZ3 (3 validated targets in B-cell malignancies). Also degrades Ibrutinib (Cat. No. 6813) -resistant C481S-BTK mutant cancer cells. Exhibits no binding against a panel of 468 kinases at 1 M. Reduces tumor burden and extends survival in lymphoma patient-derived xenograft models.

catalog number base :

7160

product keywords :

DD03-171 Potent selective BTK active degraders degrades IKFZ1 IKFZ3 C481S-BTK B-cell malignancies Bruton tyrosine kinase PROTAC PROTACs targeted protein degradation tpd Active Degraders Brutons Tyrosine Kinase (BTK) 7160, target protein knockdown, PROTAC, SNIPER

extended description :

Potent and selective BTK Degrader

chemical name text :

4-(1,1-Dimethylethyl)-N-[3-[6-[[4-[[4-[6-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]acetyl]amino]hexyl]-1-piperazinyl]carbonyl]phenyl]amino]-4,5-dihydro-4-methyl-5-oxo-2-pyrazinyl]-2-methylphenyl]benzamide

formula :

C 55 H 62 N 10 O 8

formula text :

C55H62N10O8

cas num :

2366132-45-6

2020 USD :

369

2021 USD :

369 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage