7160/5 | Tocris Bioscience 7160/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7160/5

catalog :

7160/5

quantity :

5 mg

price :

449 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7160 - DD 03-171 C55H62N10O8 CAS No. 2366132-45-6

product information

master code :

7160

SKU :

7160/5

product name :

DD 03-171

unit size :

5 mg

description :

Potent and selective BTK Degrader (PROTAC )

target :

Active Degraders

category :

Small Molecules

purity :

98%

observed molecular weight :

991.16

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

DD 03-171 is a potent and selective BTK Degrader (PROTAC ) (DC50 = 5.1 nM); degrades BTK in a proteasome- and CRBN-dependent manner. Suppresses BTK signaling and proliferation in mantle cell lymphoma (MCL) cells by degrading BTK, IKFZ1, and IKFZ3 (3 validated targets in B-cell malignancies). Also degrades Ibrutinib (Cat. No. 6813) -resistant C481S-BTK mutant cancer cells. Exhibits no binding against a panel of 468 kinases at 1 M. Reduces tumor burden and extends survival in lymphoma patient-derived xenograft models. . BTK antibodies validated for Western Blot also available: Catalog # MAB5807 and NBP2-02472 . . PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license .

top caption :

Potent and selective BTK Degrader (PROTAC )

extended description :

Potent and selective BTK Degrader (PROTAC )

chemical name text :

4-(1,1-Dimethylethyl)-N-[3-[6-[[4-[[4-[6-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]acetyl]amino]hexyl]-1-piperazinyl]carbonyl]phenyl]amino]-4,5-dihydro-4-methyl-5-oxo-2-pyrazinyl]-2-methylphenyl]benzamide

formula :

C55H62N10O8

formula text :

C55H62N10O8

cas num :

2366132-45-6

USD :

449 USD

product details :

Potent and selective BTK Degrader (PROTAC )

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage