7158/10 | Tocris Bioscience 7158/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7158/10

catalog :

7158/10

quantity :

10 mg

price :

313 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7158 - FMF-04-159-2 C28H30Cl3N7O5S CAS No. 2364489-81-4

product information

master code :

7158

SKU :

7158/10

product name :

FMF-04-159-2

unit size :

10 mg

description :

Potent covalent CDK14 and CDK16 inhibitor; also inhibits other TAIRE kinase family members

target :

Cyclin-dependent Kinase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

683.01

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

FMF-04-159-2 is a potent inhibitor of CDK14 and CDK16 (IC50 = 40 nM for CDK14 in cellular BRET assay; IC50 values are 88 and 10 nM for CDK14 and CDK16 in kinase activity inhibition assay, respectively). Inhibits other TAIRE kinase family members at 1 M (CDK17 and CDK18). Also binds CDK2 (IC50 = 256 nM). Displays covalent binding of CDK14, with binding sustained after washout. Causes cell cycle arrest at G2/M in cancer cell lines. . Reversible control FMF-04-159-R (Cat. No. 7159) also available.

top caption :

Potent covalent CDK14 and CDK16 inhibitor; also inhibits other TAIRE kinase family members

extended description :

Potent covalent CDK14 and CDK16 inhibitor; also inhibits other TAIRE kinase family members

chemical name text :

N-[1-[[3-[[(2E)-4-(Dimethylamino)-1-oxo-2-buten-1-yl]amino]phenyl]sulfonyl]-4-piperidinyl]-4-[(2,4,6- trichlorobenzoyl)amino]-1H-pyrazole-3-carboxamide

formula :

C28H30Cl3N7O5S

formula text :

C28H30Cl3N7O5S

cas num :

2364489-81-4

USD :

313 USD

product details :

Potent covalent CDK14 and CDK16 inhibitor; also inhibits other TAIRE kinase family members

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage