Cambinol | Tocris Bioscience 7137/10 product information

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product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Cambinol

catalog :

7137/10

quantity :

10 mg (also 50 mg)

price :

136 USD

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

7137

SKU :

7137/10

product name :

Cambinol

description :

nSMase2 inhibitor

target :

SMPD2

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

360.43

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Cambinol is a neutral sphingomyelinase-2 (nSMase2) inhibitor (Ki = 7 IC50 ~ 7.7 M). In vitro , Cambinol suppresses extracellular vesicle production and inhibits cell-to-cell tau propagation in tau biosensor cells. In vivo , Cambinol decreases tumor necrosis factor- or interleukin-1 -induced increases of ceramide and cell death in primary neurons. Cambinol is neuroprotective and brain penetrant. Cambinol inhibits the activity of human SIRT1 and SIRT2 and exerts antitumor activity in vitro and in mouse xenograft studies.

product keywords :

neutral sphingomyelinase 2 nSMase2 inhibition inhibitors inhibits Sphingomyelin SMase brain penetrant SIRT1 SIRT2 antitumor tau Other Hydrolases Class III HDACs (Sirtuins) 7137, SMPD 2, Neutral Sphingomyelinase, Lyso-Platelet-Activating Factor-Phospholipase C, Lyso-PAF-PLC, N-SMase, NSMase, ISC1, NSMASE1, NSMASE

extended description :

nSMase2 inhibitor

chemical name text :

2,3-Dihydro-5-[(2-hydroxy-1-naphthalenyl)methyl]-6-phenyl-2-thioxo-4(1H)-pyrimidinone

formula :

C21H16N2O2S

formula text :

C21H16N2O2S

cas num :

14513-15-6

USD :

134

USD 2025 :

136 USD

product details :

nSMase2 inhibitor