7135/10 | Tocris Bioscience 7135/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7135/10

catalog :

7135/10

quantity :

10 mg (also 50 mg)

price :

175 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7135 - AKOS 022 C22H21ClF3N3O3 CAS No. 878983-38-1

product information

master code :

7135

SKU :

7135/10

product name :

AKOS 022

unit size :

10 mg (also 50 mg)

description :

Voltage-dependent anion channel (VDAC) inhibitor

target :

Ion Channel Modulators

category :

Small Molecules

purity :

98%

observed molecular weight :

467.87

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

AKOS 022 is a voltage-dependent anion channel (VDAC; Kd = 154 M) inhibitor, which reduces channel conductance. In HEK-293 cells, AKOS 022 inhibits selenium-induced VDAC oligomerization, cytochrome C release from mitochondria and apoptosis (IC50 values range from 3.3 to 3.6 M). AKOS 022 also prevents glucotoxicity-mediated overexpression of VDAC1 in INS-1 cells.

top caption :

Voltage-dependent anion channel (VDAC) inhibitor

extended description :

Voltage-dependent anion channel (VDAC) inhibitor

chemical name text :

1-(4-Chlorophenyl)-3-[4-[[4-(trifluoromethoxy)phenyl]amino]-1-piperidinyl]-2,5-pyrrolidinedione

formula :

C22H21ClF3N3O3

formula text :

C22H21ClF3N3O3

cas num :

878983-38-1

USD :

175 USD

product details :

Voltage-dependent anion channel (VDAC) inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage