7134/10 | Tocris Bioscience 7134/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7134/10

catalog :

7134/10

quantity :

10 mg (also 50 mg)

price :

170 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7134 - ARN 14494 C24H32N4O3 CAS No. 1037834-43-7

product information

master code :

7134

SKU :

7134/10

product name :

ARN 14494

unit size :

10 mg (also 50 mg)

description :

Potent serine palmitoyltransferase inhibitor

target :

Other Transferase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

424.55

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

ARN 14494 is a potent serine palmitoyltransferase inhibitor (IC50 = 27.3 nM). ARN 14494 inhibits synthesis of long chain ceramides and dihydroceramides in an in vitro model of Alzheimer s diease. The compound prevents the synthesis of proinflammatory cytokines and the oxidative stress-related enzymes iNOS and COX-2 in mouse primary cortical astrocytes. ARN 14494 is neuroprotective against -amyloid 1-42 induced neurotoxicity in primary cortical neurons co-cultured with astrocytes.

top caption :

Potent serine palmitoyltransferase inhibitor

extended description :

Potent serine palmitoyltransferase inhibitor

chemical name text :

rel-1-[1-[2-[(3aR,6aS)-Hexahydrocyclopenta[c]pyrrol-2(1H)-yl]-2-oxoethyl]-4-piperidinyl]-2,3-dihydro-N-methyl-2-oxo-1H-indole-5-carboxamide

formula :

C24H32N4O3

formula text :

C24H32N4O3

cas num :

1037834-43-7

USD :

170 USD

product details :

Potent serine palmitoyltransferase inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage