7129/10 | Tocris Bioscience 7129/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7129/10

catalog :

7129/10

quantity :

10 mg (also 50 mg)

price :

134 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7129 - RA 2 C22H16F2O6 CAS No. 1867107-62-7

product information

master code :

7129

SKU :

7129/10

product name :

RA 2

unit size :

10 mg (also 50 mg)

description :

Potent negative modulator of KCa2.3 and KCa3.1 channels

target :

Ca2+-Activated Potassium Channel Modulators

category :

Small Molecules

purity :

98%

observed molecular weight :

414.36

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

RA 2 is a potent negative modulator of calcium-activated potassium channels KCa2.3 and KCa3.1 (IC50 values are 2 and 17 nM, respectively), which displays 55-fold selectively for KCa2 and KCa3.1 over other KCa, Kv and Kir channels. In ex vivo porcine coronary endothelium, RA 2 inhibits SKA 31 (Cat. No. 3670)-induced KCa2/KCa3.1 currents and TRAM 34 (Cat. No. 2946)-insensitive KCa2 currents. Reduces heart rate in mice in a KCa3.1-dependent manner.

top caption :

Potent negative modulator of KCa2.3 and KCa3.1 channels

extended description :

Potent negative modulator of KCa2.3 and KCa3.1 channels

chemical name text :

1,3-Phenylenebis(methylene)bis(3-fluoro-4-hydroxybenzoate)

formula :

C22H16F2O6

formula text :

C22H16F2O6

cas num :

1867107-62-7

USD :

134 USD

product details :

Potent negative modulator of KCa2.3 and KCa3.1 channels

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage