7120/5 | Tocris Bioscience 7120/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7120/5

catalog :

7120/5

quantity :

5 mg

price :

445 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7120 - SNIPER(ER)-87 C59H73N5O10S CAS No. 2222354-91-6

product information

master code :

7120

SKU :

7120/5

product name :

SNIPER(ER)-87

unit size :

5 mg

description :

Potent and selective ER Degrader (SNIPER)

target :

Active Degraders

category :

Small Molecules

purity :

98%

observed molecular weight :

1044.32

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SNIPER(ER)-87 is a potent and selective estrogen receptor (ER ) Degrader (Specific and Nongenetic IAP-dependent Protein Erasers or SNIPER) (DC50 = 3 nM). SNIPER(ER)-87 comprises the IAP binding ligand LCL 161 (Cat. No. 7178) joined by a linker to the estrogen-binding moiety 4-hydroxytamoxifen (Cat. No. 3412). The product decreases ER levels in breast cancer cells in vitro and in mouse ovaries in vivo . SNIPER(ER)-87 also reduces ER levels and inhibits tumor proliferation in breast cancer xenograft mouse models. ER alpha/NR3A1 antibodies validated for Simple Western (automated Western) instruments and Western Blot also available: Catalog # AF 5715 and MAB57151 .

top caption :

Potent and selective ER Degrader (SNIPER)

extended description :

Potent and selective ER Degrader (SNIPER)

chemical name text :

(2S)-N-[(1S)-1-Cyclohexyl-2-[(2S)-2-[4-[3-[[14-[4-[1-(4-hydroxyphenyl)-2-phenyl-1-buten-1-yl]phenoxy]-12-methyl-11-oxo-3,6,9-trioxa-12-azatetradec-1-yl]oxy]benzoyl]-2-thiazolyl]-1-pyrrolidinyl]-2-oxoethyl]-2-(methylamino)propanamide

formula :

C59H73N5O10S

formula text :

C59H73N5O10S

cas num :

2222354-91-6

USD :

445 USD

product details :

Potent and selective ER Degrader (SNIPER)

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage