Miro1 Reducer | Tocris Bioscience 7091 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Miro1 Reducer

catalog :

7091

quantity :

10 mg (also 50 mg)

price :

155 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7091 - Miro1 Reducer C20H16FN7O.HCl

product information

brand :

Tocris

master code :

7091

SKU :

7091/10

product name :

Miro1 Reducer

description :

Promotes mitochondrial Rho GTPase 1 (Miro1) degradation

target :

Rhot1

category :

Small Molecules

unit size :

10 mg (also 50 mg)

main entrez gene id :

55288

purity :

98%

observed molecular weight :

425.85

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Promotes proteasomal degradation of Miro1 (mitochondrial Rho GTPase 1). Reduces Miro1 levels in fibroblasts from Parkinson s disease (PD) patients (IC50 = 7.8 M). Exhibits no significant effect on related outer mitochondrial membrane protein Mitofusin. Reduces stress-induced degeneration of dopaminergic neurons derived from PD patient iPSCs. Rescues age-dependent neuronal loss and prolongs lifespan in fly PD models.

catalog number base :

7091

product keywords :

1360287-51-9 miro1 proteasomal degradation reducer reduces mitochondrial Rho GTPase 1 RHOT1 Rho 7091, Miro 1, Rho t1, Rho GTPase, E3 Ubiquitin Ligase substrate, Parkin substrate, Mitochondrial GTPase

extended description :

Promotes mitochondrial Rho GTPase 1 (Miro1) degradation

chemical name text :

N-(3-Fluorophenyl)-N -[4-[[6-(1H-imidazol-1-yl)-4-pyrimidinyl]amino]phenyl]urea hydrochloride

formula :

C 20 H 16 FN 7 O.HCl

formula text :

C20H16FN7O.HCl

2020 USD :

155

2021 USD :

155 USD

alt names :

ARHT1, EC 3.6.5, EC 3.6.5.-, FLJ11040, FLJ12633, hMiro-1, MIRO-1mitochondrial Rho GTPase 1, mitochondrial Rho 1, rac-GTP binding protein-like protein, Rac-GTP-binding protein-like protein, Ras homolog gene family member T1, ras homolog gene family, member T1, Rhot1

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage