7091/10 | Tocris Bioscience 7091/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7091/10

catalog :

7091/10

quantity :

10 mg (also 50 mg)

price :

199 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Cangkrama M, Liu H, Whipman J, Zubair M, Matsushita M, Di Filippo M, et al. A Protumorigenic mDia2-MIRO1 Axis Controls Mitochondrial Positioning and Function in Cancer-Associated Fibroblasts. Cancer Res. 2022;82:3701-3717 pubmed publisher

image

image 1 :

Cat.No. 7091 - Miro1 Reducer C20H16FN7O.HCl

product information

master code :

7091

SKU :

7091/10

product name :

Miro1 Reducer

unit size :

10 mg (also 50 mg)

description :

Promotes mitochondrial Rho GTPase 1 (Miro1) degradation

target :

Miro1/Rhot1

category :

Small Molecules

purity :

98%

observed molecular weight :

425.85

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Miro1 Reducer is a promotes proteasomal degradation of Miro1 (mitochondrial Rho GTPase 1). Reduces Miro1 levels in fibroblasts from Parkinson s disease (PD) patients (IC50 = 7.8 M). Exhibits no significant effect on related outer mitochondrial membrane protein Mitofusin. Reduces stress-induced degeneration of dopaminergic neurons derived from PD patient iPSCs. Rescues age-dependent neuronal loss and prolongs lifespan in fly PD models.

top caption :

Promotes mitochondrial Rho GTPase 1 (Miro1) degradation

extended description :

Promotes mitochondrial Rho GTPase 1 (Miro1) degradation

chemical name text :

N-(3-Fluorophenyl)-N -[4-[[6-(1H-imidazol-1-yl)-4-pyrimidinyl]amino]phenyl]urea hydrochloride

formula :

C20H16FN7O.HCl

formula text :

C20H16FN7O.HCl

cas num :

2624336-91-8

USD :

199 USD

product details :

Promotes mitochondrial Rho GTPase 1 (Miro1) degradation

alt names :

ARHT1, EC 3.6.5, EC 3.6.5.-, FLJ11040, FLJ12633, hMiro-1, MIRO-1mitochondrial Rho GTPase 1, mitochondrial Rho 1, rac-GTP binding protein-like protein, Rac-GTP-binding protein-like protein, Ras homolog gene family member T1, ras homolog gene family, member T1, Rhot1

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage