7089/2 | Tocris Bioscience 7089/2 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7089/2

catalog :

7089/2

quantity :

2 mg

price :

691 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7089 - CSN5i-3 C28H29F2N5O2 CAS No. 2375740-98-8

product information

master code :

7089

SKU :

7089/2

product name :

CSN5i-3

unit size :

2 mg

description :

Potent and selective CSN5 (COP9 signalosome) inhibitor

target :

Ubiquitin Ligase (E3) Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

505.57

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

CSN5i-3 is a potent and selective CSN5 (COP9 signalosome) inhibitor. It inhibits deneddylation of NEDD8-modifed CRLs (IC50 = 5.8 nM), keeping them in the neddylated state, and leading to inactivation of a subset of CRLs by inducing degradation of their substrate receptor module (SRM). In A2780 ovarian cancer cells, CSN5i-3 down-regulates the expression of COPS5 and arrest cells at S-phase. In HUVECs in vitro and in zebrafish embryos in vivo , CSN5i-3 induces endothelial barrier disruption and increases macromolecule leakage by increasing the expression and activity of RhoGTPases. CSN5i-3 also inhibits the growth of lymphoma cell xenografts in mice. Orally bioavailable. . The negative control CSN5i-3-NEG (Cat. No. 7532) is also available.

top caption :

Novartis vs Bio-Techne batch comparison for CSN5i-3

extended description :

Potent and selective CSN5 (COP9 signalosome) inhibitor

chemical name text :

3-(Difluoromethyl)-N-(6-((5S,6S)-6-hydroxy-6,7,8,9-tetrahydro-5H-imidazo[1,5-a]azepin-5-yl)-[1,10-biphenyl]-3-yl)-1-isopropyl-1H-pyrazole-5-carboxamide

formula :

C28H29F2N5O2

formula text :

C28H29F2N5O2

cas num :

2375740-98-8

USD :

691 USD

product details :

Potent and selective CSN5 (COP9 signalosome) inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage