7086/10 | Tocris Bioscience 7086/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7086/10

catalog :

7086/10

quantity :

10 mg

price :

173 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Jackson C, Durandt C, Janse van Rensburg I, Praloran V, Brunet de la Grange P, Pepper M. Targeting the aryl hydrocarbon receptor nuclear translocator complex with DMOG and Stemregenin 1 improves primitive hematopoietic stem cell expansion. Stem Cell Res. 2017;21:124-131 pubmed publisher

image

image 1 :

Cat.No. 7086 - StemRegenin 1 C24H23N5OS CAS No. 1227633-49-9

product information

master code :

7086

SKU :

7086/10

product name :

StemRegenin 1

unit size :

10 mg

description :

Aryl hydrocarbon receptor (AhR) antagonist; promotes HSC expansion and engraftment

target :

Aryl Hydrocarbon Receptor Antagonists

category :

Small Molecules

purity :

98%

observed molecular weight :

429.54

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

StemReginin 1 is an aryl hydrocarbon receptor (AHR) antagonist (IC50 = 127 nM). StemReginin 1 exhibits no inhibitory activity against a panel of 61 kinases and preferentially inhibits human AHR. StemReginin 1 promotes the expansion of CD34+ cells ex vivo . In hematopoietic stem cell (HSC) culture, the compound induces a 50-fold increase in CD34-expressing cells, and HSCs cultured with StemReginin 1 show increased engraftment in mice. Combination of StemReginin 1 with DMOG (Cat. No. 4408) increases the proportion of primitive HSCs and improves long-term engraftment. The product also promotes expansion of human promyelocytic leukemia cell line NB4.

top caption :

Aryl hydrocarbon receptor (AhR) antagonist; promotes HSC expansion and engraftment

extended description :

Aryl hydrocarbon receptor (AhR) antagonist; promotes HSC expansion and engraftment

chemical name text :

4-[2-[[2-Benzo[b]thien-3-yl-9-(1-methylethyl)-9H-purin-6-yl]amino]ethyl]phenol

formula :

C24H23N5OS

formula text :

C24H23N5OS

cas num :

1227633-49-9

USD :

173 USD

product details :

Aryl hydrocarbon receptor (AhR) antagonist; promotes HSC expansion and engraftment

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage