7082/10 | Tocris Bioscience 7082/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7082/10

catalog :

7082/10

quantity :

10 mg (also 50 mg)

price :

137 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Marsango S, Ward R, Jenkins L, Butcher A, Al Mahmud Z, Dwomoh L, et al. Selective phosphorylation of threonine residues defines GPR84-arrestin interactions of biased ligands. J Biol Chem. 2022;298:101932 pubmed publisher

image

image 1 :

Cat.No. 7082 - DL 175 C17H14ClNO2

product information

master code :

7082

SKU :

7082/10

product name :

DL 175

unit size :

10 mg (also 50 mg)

description :

Potent and selective GPR84 agonist

target :

Free Fatty Acid Receptor Agonists

category :

Small Molecules

purity :

98%

observed molecular weight :

299.75

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

DL 175 is a potent and selective GPR84 biased agonist (EC50 = 33 nM). Exhibits no significant activity in a panel of 168 other GPCRs. Exhibits bias for G protein signaling pathways. Induces morphological changes in primary murine bone marrow-derived macrophages (BMDMs) in a cellular impedance assay, and promotes phagocytosis by M1 polarized U937 cells. Induces migration of primary human monocytes, but has no effect on macrophage chemotaxis.

top caption :

Potent and selective GPR84 agonist

extended description :

Potent and selective GPR84 agonist

chemical name text :

3-(2-((4-Chloronaphthalen-1-yl)oxy)ethyl)pyridine 1-oxide

formula :

C17H14ClNO2

formula text :

C17H14ClNO2

cas num :

2487253-25-6

USD :

137 USD

product details :

Potent and selective GPR84 agonist

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage