LY 2886721 Hydrochloride | Tocris Bioscience 7081 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

LY 2886721 Hydrochloride

catalog :

7081

quantity :

10 mg (also 50 mg)

price :

215 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7081 - LY 2886721 Hydrochloride C18H16F2N4O2S.HCl CAS No. 1262036-49-6

product information

brand :

Tocris

master code :

7081

SKU :

7081/10

product name :

LY 2886721 Hydrochloride

description :

Potent and selective -secretase (BACE) inhibitor

target :

Additional Synthetic Protease Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

426.87

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective -secretase (BACE) inhibitor (IC50 values are 10.2 and 20.3 nM for human BACE2 and BACE1, respectively). Displays 5,000-fold selectivity for BACE over other proteases including cathepsin D, pepsin and renin. Inhibits A 1-40 and A 1-42 production in cells expressing mutated APP. Reduces hippocampal and cortical A and sAPP levels in an Alzheimer s disease mouse model.

catalog number base :

7081

product keywords :

LY2886721 Hydrochloride BACE1 BACE2 inhibitors inhibits amyloid beta ab40 ab42 beta secretase b-secretase alzheimers disease AD Other Proteases Amyloid Beta Peptides 7081,

extended description :

Potent and selective -secretase (BACE) inhibitor

chemical name text :

N-[3-[(4aS,7aS)-2-Amino-4a,5-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(7H)-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide hydrochloride

formula :

C 18 H 16 F 2 N 4 O 2 S.HCl

formula text :

C18H16F2N4O2S.HCl

cas num :

1262036-49-6

2020 USD :

215

2021 USD :

215 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage