7081/10 | Tocris Bioscience 7081/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7081/10

catalog :

7081/10

quantity :

10 mg (also 50 mg)

price :

270 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7081 - LY 2886721 Hydrochloride C18H16F2N4O2S.HCl CAS No. 1262036-49-6

product information

master code :

7081

SKU :

7081/10

product name :

LY 2886721 Hydrochloride

unit size :

10 mg (also 50 mg)

description :

Potent and selective -secretase (BACE) inhibitor

target :

Additional Synthetic Protease Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

426.87

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

LY 2886721 Hydrochloride is a potent and selective -secretase (BACE) inhibitor (IC50 values are 10.2 and 20.3 nM for human BACE2 and BACE1, respectively). Displays 5,000-fold selectivity for BACE over other proteases including cathepsin D, pepsin and renin. Inhibits A 1-40 and A 1-42 production in cells expressing mutated APP. Reduces hippocampal and cortical A and sAPP levels in an Alzheimer s disease mouse model.

top caption :

Potent and selective -secretase (BACE) inhibitor

extended description :

Potent and selective -secretase (BACE) inhibitor

chemical name text :

N-[3-[(4aS,7aS)-2-Amino-4a,5-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(7H)-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide hydrochloride

formula :

C18H16F2N4O2S.HCl

formula text :

C18H16F2N4O2S.HCl

cas num :

1262036-49-6

USD :

270 USD

product details :

Potent and selective -secretase (BACE) inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage