Ruxolitinib | Tocris Bioscience 7064 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Ruxolitinib

catalog :

7064

quantity :

50 mg

price :

229 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7064 - Ruxolitinib C17H18N6 CAS No. 941678-49-5

product information

brand :

Tocris

master code :

7064

SKU :

7064/50

product name :

Ruxolitinib

description :

Potent and selective JAK1/JAK2 inhibitor; orally bioavailable

target :

JAK Kinase Inhibitors

category :

Small Molecules

unit size :

50 mg

purity :

98%

observed molecular weight :

306.37

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective JAK1/2 inhibitor (IC50 values are 3.3 and 2.8 nM, respectively). Exhibits selectivity for JAK1/2 over Tyk2 and JAK3 (~6-fold and 130-fold, respectively). Exhibits no significant inhibition against a commercial panel of 26 additional kinases. Inhibits JAK2V617F-mediated signaling and proliferation in Ba/F3 cells and HEL cells. Increases survival rates in a JAK2V617F-driven mouse model. Identified as targeting human host proteins that interact with SARS-CoV-2.Orally bioavailable. . Phosphate salt (Cat. No. 7048) also available.

catalog number base :

7064

product keywords :

Potent selective JAK1/JAK2 inhibitors inhibits JAK1 JAK2 orally bioavailable active in vivo COVID-19 SARS-CoV-2 severe acute respiratory syndrome INCB018424 JAK Kinase COVID-19 Coronavirus 7064,

extended description :

Potent and selective JAK1/JAK2 inhibitor; orally bioavailable

chemical name text :

(3R)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile

formula :

C 17 H 18 N 6

formula text :

C17H18N6

cas num :

941678-49-5

2020 USD :

229

2021 USD :

229 USD

alt names :

INCB018424

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage