Tasquinimod | Tocris Bioscience 7051 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Tasquinimod

catalog :

7051

quantity :

25 mg

price :

295 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Isaacs J, Antony L, Dalrymple S, Brennen W, Gerber S, Hammers H, et al. Tasquinimod Is an Allosteric Modulator of HDAC4 survival signaling within the compromised cancer microenvironment. Cancer Res. 2013;73:1386-99 pubmed publisher

image

image 1 :

Cat.No. 7051 - Tasquinimod C20H17F3N2O4 CAS No. 254964-60-8

product information

brand :

Tocris

master code :

7051

SKU :

7051/25

product name :

Tasquinimod

description :

High affinity HDAC4 negative allosteric modulator; also binds S100A9; antiangiogenic

target :

Class II Histone Deacetylases Inhibitors

category :

Small Molecules

unit size :

25 mg

purity :

98%

observed molecular weight :

406.36

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

High affinity negative allosteric modulator of HDAC4 (Kd = 10 - 30 nM). Binds the regulatory Zn2+ binding domain of HDAC4. Suppresses hypoxia-induced decrease in histone acetylation in human prostate cancer cells in vitro . Also binds S100A9. Antiangiogenic. Inhibits endothelial sprouting in vitro and growth of prostate tumor xenografts in nude mice. Orally bioavailable.

catalog number base :

7051

product keywords :

High affinity HDAC4 histone deacetylase negative allosteric modulators modulates NAM orally bioavailable antiangiogenic binds S100A9 Class II HDACs 7051,

extended description :

High affinity HDAC4 negative allosteric modulator; also binds S100A9; antiangiogenic

chemical name text :

1,2-dihydro-4-hydroxy-5-methoxy-N,1-dimethyl-2-oxo-N-[4-(trifluoromethyl)phenyl]-3-quinolinecarboxamide

formula :

C 20 H 17 F 3 N 2 O 4

formula text :

C20H17F3N2O4

cas num :

254964-60-8

2020 USD :

295

2021 USD :

295 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage