7051/5 | Tocris Bioscience 7051/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7051/5

catalog :

7051/5

quantity :

5 mg (also 25 mg)

price :

96 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Isaacs J, Antony L, Dalrymple S, Brennen W, Gerber S, Hammers H, et al. Tasquinimod Is an Allosteric Modulator of HDAC4 survival signaling within the compromised cancer microenvironment. Cancer Res. 2013;73:1386-99 pubmed publisher

image

image 1 :

Cat.No. 7051 - Tasquinimod C20H17F3N2O4 CAS No. 254964-60-8

product information

master code :

7051

SKU :

7051/5

product name :

Tasquinimod

unit size :

5 mg (also 25 mg)

description :

High affinity HDAC4 negative allosteric modulator; also binds S100A9; antiangiogenic

target :

Class II Histone Deacetylases Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

406.36

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Tasquinimod is a high affinity negative allosteric modulator of HDAC4 (Kd = 10 - 30 nM). Binds the regulatory Zn2+ binding domain of HDAC4. Suppresses hypoxia-induced decrease in histone acetylation in human prostate cancer cells in vitro . Also binds S100A9. Antiangiogenic. Inhibits endothelial sprouting in vitro and growth of prostate tumor xenografts in nude mice. Orally bioavailable.

top caption :

High affinity HDAC4 negative allosteric modulator; also binds S100A9; antiangiogenic

extended description :

High affinity HDAC4 negative allosteric modulator; also binds S100A9; antiangiogenic

chemical name text :

1,2-dihydro-4-hydroxy-5-methoxy-N,1-dimethyl-2-oxo-N-[4-(trifluoromethyl)phenyl]-3-quinolinecarboxamide

formula :

C20H17F3N2O4

formula text :

C20H17F3N2O4

cas num :

254964-60-8

USD :

96 USD

product details :

High affinity HDAC4 negative allosteric modulator; also binds S100A9; antiangiogenic

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage