7049/10 | Tocris Bioscience 7049/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7049/10

catalog :

7049/10

quantity :

10 mg (also 50 mg)

price :

78 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Hilberg F, Roth G, Krssak M, Kautschitsch S, Sommergruber W, Tontsch Grunt U, et al. BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer Res. 2008;68:4774-82 pubmed publisher

image

image 1 :

Cat.No. 7049 - Nintedanib C31H33N5O4 CAS No. 656247-17-5

product information

master code :

7049

SKU :

7049/10

product name :

Nintedanib

unit size :

10 mg (also 50 mg)

description :

Potent VEGFR, PDGFR and FGFR inhibitor

target :

VEGF Receptor Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

539.64

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Nintedanib is a potent inhibitor of vascular endothelial growth factor receptors (VEGFRs), platelet-derived growth factor receptors (PDGFRs) and fibroblast growth factor receptors (FGFRs) (IC50 values are 13 - 34 nM for VEGFR subtypes, 59 - 65 nM for PDGFR subtypes, 37 - 108 nM for FGFR subtypes). Also inhibits Flt-3, Lck, Lyn and Src (IC50 values are 25 - 200 nM). Inhibits proliferation in VEGF-stimulated endothelial cells, and PDGF-stimulated pericytes and vascular smooth muscle cells. Reduces vessel density and integrity, and inhibits tumor growth in a mouse tumor xenograft model.

top caption :

Potent VEGFR, PDGFR and FGFR inhibitor

extended description :

Potent VEGFR, PDGFR and FGFR inhibitor

chemical name text :

Methyl (Z)-3-[[[4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene]-2-oxoindoline-6-carboxylate

formula :

C31H33N5O4

formula text :

C31H33N5O4

cas num :

656247-17-5

USD :

78 USD

product details :

Potent VEGFR, PDGFR and FGFR inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage