7030/10 | Tocris Bioscience 7030/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7030/10

catalog :

7030/10

quantity :

10 mg (also 50 mg)

price :

343 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Liu S, Zhang Z, Li L, Yao L, Ma Z, Li J. ADAM10- and γ-secretase-dependent cleavage of the transmembrane protein PTPRT attenuates neurodegeneration in the mouse model of Alzheimer's disease. FASEB J. 2023;37:e22734 pubmed publisher
Sommer D, Corstjens I, Sanchez S, Dooley D, Lemmens S, Van Broeckhoven J, et al. ADAM17-deficiency on microglia but not on macrophages promotes phagocytosis and functional recovery after spinal cord injury. Brain Behav Immun. 2019;: pubmed publisher

image

image 1 :

Cat.No. 7030 - GW 280264X C28H41N5O6S CAS No. 866924-39-2

product information

master code :

7030

SKU :

7030/10

product name :

GW 280264X

unit size :

10 mg (also 50 mg)

description :

Potent ADAM10 and ADAM17 inhibitor

target :

Synthetic Metalloprotease Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

575.73

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

GW 280264X is a potent ADAM (A Disintegrin and Metalloproteinase) 17 and ADAM10 inhibitor (IC50 values of 8 nM and 11.5 nM, respectively). It inhibits constitutive and PMA-inducible CX3CL1 shedding and increases adhesive properties in CX3CL1 transfected cells (IC50 = 1 M in COS-7 and ECV-304 cells). GW 280264X treatment in mice significantly improves functional recovery after spinal cord injury.

top caption :

Potent ADAM10 and ADAM17 inhibitor

extended description :

Potent ADAM10 and ADAM17 inhibitor

chemical name text :

Phenylmethyl N-[(5S)-5-[[(2R,3S)-3-(formylhydroxyamino)-2-(2-methylpropyl)-1-oxohexyl]amino]-6-oxo-6-(2-thiazolylamino)hexyl]carbamate

formula :

C28H41N5O6S

formula text :

C28H41N5O6S

cas num :

866924-39-2

USD :

343 USD

product details :

Potent ADAM10 and ADAM17 inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage