7029/10 | Tocris Bioscience 7029/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7029/10

catalog :

7029/10

quantity :

10 mg

price :

333 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7029 - GX 201 C25H27ClF4N2O4S CAS No. 1788071-27-1

product information

master code :

7029

SKU :

7029/10

product name :

GX 201

unit size :

10 mg

description :

Potent and selective Nav1.7 blocker; analgesic

target :

Voltage-gated Sodium Channel Blockers

category :

Small Molecules

purity :

98%

observed molecular weight :

563

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

GX 201 is a potent and selective Nav1.7 blocker (IC50 = 3.2 nM). Exhibits 10x selectivity for Nav1.7 over Nav1.1, Nav1.2, and Nav1.6 channels. Displays prolonged residency time on the Nav1.7 channel. Chronic dosing increases compound potency ~10-fold and provides efficacy that persists after the compound has cleared from plasma. Suppresses neuropathic pain in a mouse diabetic neuropathy model. Analgesic.

top caption :

Potent and selective Nav1.7 blocker; analgesic

extended description :

Potent and selective Nav1.7 blocker; analgesic

chemical name text :

4-[[1-[[2-Chloro-5-(trifluoromethyl)phenyl]methyl]-4-piperidinyl]methoxy]-5-cyclopropyl-2-fluoro-N-(methylsulfonyl)benzamide

formula :

C25H27ClF4N2O4S

formula text :

C25H27ClF4N2O4S

cas num :

1788071-27-1

USD :

333 USD

product details :

Potent and selective Nav1.7 blocker; analgesic

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage