LY 2033298 | Tocris Bioscience 7027 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

LY 2033298

catalog :

7027

quantity :

25 mg

price :

759 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

7027

SKU :

7027/25

product name :

LY 2033298

description :

Selective positive allosteric modulator of M4 receptors; active in vivo; antipsychotic

target :

mAChR M4 Modulators

category :

Small Molecules

unit size :

25 mg

purity :

98%

observed molecular weight :

311.79

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective positive allosteric modulator of M4 receptor (KB = 200 nM, = 35); increases the potency of acetylcholine by 40-fold. Exhibits no effect at hM1/3/5 receptors and a small effect at hM2 (KB = 1 M = 3.7). Potentiates other full and partial orthosteric agonists, including Carbachol, Oxotremorine-M, and McN-A343 . Does not affect binding of antagonist NMS. Active in vivo . Antipsychotic. . indicates the degree of allosteric enhancement when both orthosteric and allosteric sites are occupied (derived from the allosteric ternary complex model).

catalog number base :

7027

product keywords :

LY2033298 Selective positive allosteric modulators M4 receptors PAMs active in vivo antipsychotic acetylcholine modulates M4 Receptors 7027,

extended description :

Selective positive allosteric modulator of M4 receptors; active in vivo; antipsychotic

chemical name text :

3-Amino-5-chloro-N-cyclopropyl-6-methoxy-4-methylthieno[2,3-b]pyridine-2-carboxamide

formula :

C 13 H 14 ClN 3 O 2 S

formula text :

C13H14ClN3O2S

cas num :

886047-13-8

2020 USD :

759

2021 USD :

759 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage