7027/5 | Tocris Bioscience 7027/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7027/5

catalog :

7027/5

quantity :

5 mg (also 25 mg)

price :

245 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7027 - LY 2033298 C13H14ClN3O2S CAS No. 886047-13-8

product information

master code :

7027

SKU :

7027/5

product name :

LY 2033298

unit size :

5 mg (also 25 mg)

description :

Selective positive allosteric modulator of M4 receptors; active in vivo; antipsychotic

target :

mAChR M4 Modulators

category :

Small Molecules

purity :

98%

observed molecular weight :

311.79

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

LY 2033298 is a selective positive allosteric modulator of M4 receptor (KB = 200 nM, = 35); increases the potency of acetylcholine by 40-fold. Exhibits no effect at hM1/3/5 receptors and a small effect at hM2 (KB = 1 M = 3.7). Potentiates other full and partial orthosteric agonists, including Carbachol, Oxotremorine-M, and McN-A343 . Does not affect binding of antagonist NMS. Active in vivo . Antipsychotic. . indicates the degree of allosteric enhancement when both orthosteric and allosteric sites are occupied (derived from the allosteric ternary complex model).

top caption :

Selective positive allosteric modulator of M4 receptors; active in vivo; antipsychotic

extended description :

Selective positive allosteric modulator of M4 receptors; active in vivo; antipsychotic

chemical name text :

3-Amino-5-chloro-N-cyclopropyl-6-methoxy-4-methylthieno[2,3-b]pyridine-2-carboxamide

formula :

C13H14ClN3O2S

formula text :

C13H14ClN3O2S

cas num :

886047-13-8

USD :

245 USD

product details :

Selective positive allosteric modulator of M4 receptors; active in vivo; antipsychotic

storage :

Store at +4░C

more info or order :

Tocris Bioscience product webpage