Veliparib dihydrochloride | Tocris Bioscience 7026 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Veliparib dihydrochloride

catalog :

7026

quantity :

50 mg

price :

125 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7026 - Veliparib dihydrochloride C13H16N4O.2HCl CAS No. 912445-05-7

product information

brand :

Tocris

master code :

7026

SKU :

7026/50

product name :

Veliparib dihydrochloride

description :

High affinity PARP-1 and -2 inhibitor; orally bioavailable

target :

Poly(ADP-ribose) Polymerase Inhibitors

category :

Small Molecules

unit size :

50 mg

purity :

98%

observed molecular weight :

317.21

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

High affinity PARP-2 and PARP-1 inhibitor (Ki values are 2.9 and 5.2 nM, respectively). Inhibits repair of radiation-induced DNA damage and sensitizes lung cancer cells to radiation. Also increases autophagy and apoptosis in lung cancer cells. Enhances radiation-induced tumor growth delay in mice bearing lung tumor xenografts. Also chemosensitizer. Potentiates effects of temozolomide (Cat. No. 2706) in a mouse melanoma model. Orally bioavailable and brain penetrant.

catalog number base :

7026

product keywords :

PARP-1 2 inhibitors inhibits poly(ADP-ribose) polymerase radiosensitizers chemosensitizers high affinity orally bioavailable brain penetrant ABT888 ABT-888 Poly(ADP-ribose) Polymerase 7026,

extended description :

High affinity PARP-1 and -2 inhibitor; orally bioavailable

chemical name text :

2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-4-carboxamide dihydrochloride

formula :

C 13 H 16 N 4 O.2HCl

formula text :

C13H16N4O.2HCl

cas num :

912445-05-7

2020 USD :

125

2021 USD :

125 USD

alt names :

ABT-888

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage