7026/50 | Tocris Bioscience 7026/50 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7026/50

catalog :

7026/50

quantity :

50 mg

price :

158 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Li J, M Saville K, Ibrahim M, Zeng X, McClellan S, Angajala A, et al. NAD+ bioavailability mediates PARG inhibition-induced replication arrest, intra S-phase checkpoint and apoptosis in glioma stem cells. NAR Cancer. 2021;3:zcab044 pubmed publisher

image

image 1 :

Cat.No. 7026 - Veliparib dihydrochloride C13H16N4O.2HCl CAS No. 912445-05-7

product information

master code :

7026

SKU :

7026/50

product name :

Veliparib dihydrochloride

unit size :

50 mg

description :

High affinity PARP-1 and -2 inhibitor; orally bioavailable

target :

Poly(ADP-ribose) Polymerase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

317.21

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Veliparib dihydrochloride is a high affinity PARP-2 and PARP-1 inhibitor (Ki values are 2.9 and 5.2 nM, respectively). Inhibits repair of radiation-induced DNA damage and sensitizes lung cancer cells to radiation. Also increases autophagy and apoptosis in lung cancer cells. Enhances radiation-induced tumor growth delay in mice bearing lung tumor xenografts. Also chemosensitizer. Potentiates effects of temozolomide (Cat. No. 2706) in a mouse melanoma model. Orally bioavailable and brain penetrant.

top caption :

High affinity PARP-1 and -2 inhibitor; orally bioavailable

extended description :

High affinity PARP-1 and -2 inhibitor; orally bioavailable

chemical name text :

2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-4-carboxamide dihydrochloride

formula :

C13H16N4O.2HCl

formula text :

C13H16N4O.2HCl

cas num :

912445-05-7

USD :

158 USD

product details :

High affinity PARP-1 and -2 inhibitor; orally bioavailable

alt names :

ABT-888

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage