7018/10 | Tocris Bioscience 7018/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7018/10

catalog :

7018/10

quantity :

10 mg (also 50 mg)

price :

228 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7018 - CBR-470-1 C14H20ClNO4S2 CAS No. 2416095-06-0

product information

master code :

7018

SKU :

7018/10

product name :

CBR-470-1

unit size :

10 mg (also 50 mg)

description :

PGK1 inhibitor; activates Nrf2

target :

Nrf2 Activators

category :

Small Molecules

purity :

98%

observed molecular weight :

365.89

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

CBR-470-1 is a phosphoglycerate kinase 1 (PGK1) inhibitor. CBR-470-1 promotes accumulation of the reactive metabolites methylglyoxal (MGO) resulting in KEAP1 modification and dimerization, which in turn leads to activation of the Nrf2 transcriptional program. CBR-470-1 protects SH-SY5Y neuroblastoma cells from MPP+-induced cytotoxicity via the Keap1-Nrf2 cascade.

top caption :

PGK1 inhibitor; activates Nrf2

extended description :

PGK1 inhibitor; activates Nrf2

chemical name text :

(3R,4S)-rel-4-[(4-Chlorophenyl)sulfonyl]tetrahydro-N-(2-methylpropyl)-3-thiophenamine-1,1-dioxide

formula :

C14H20ClNO4S2

formula text :

C14H20ClNO4S2

cas num :

2416095-06-0

USD :

228 USD

product details :

PGK1 inhibitor; activates Nrf2

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage