EG 00229 trifluoroacetate | Tocris Bioscience 6986 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

EG 00229 trifluoroacetate

catalog :

6986

quantity :

10 mg

price :

265 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Daly J, Simonetti B, Klein K, Chen K, Williamson M, Antón Plágaro C, et al. Neuropilin-1 is a host factor for SARS-CoV-2 infection. Science. 2020;370:861-865 pubmed publisher

product information

brand :

Tocris

master code :

6986

SKU :

6986/10

product name :

EG 00229 trifluoroacetate

description :

Neuropilin 1 (NRP1) receptor antagonist; inhibits VEGFA binding to NRP1

target :

VEGF Receptor Inhibitors

category :

Small Molecules

unit size :

10 mg

purity :

98%

observed molecular weight :

611.59

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Neuropilin 1 (NRP1) antagonist; inhibits VEGFA binding to the NRP1 b1 CendR binding pocket. Has no effect on VEGFA binding to VEGFR-1 and VEGFR-2. Reduces VEGFA-induced VEGFR-2 tyrosine phosphorylation in HUVECs. Also attenuates VEGFA-induced HUVEC cell migration and reduces A549 lung carcinoma cell viability in vitro . Inhibits binding of CendR motif in S1 protein of SARS-CoV-2 to NRP1, and reduces efficiency of SARS-CoV-2 infection in Caco-2 cells.

catalog number base :

6986

product keywords :

EG00229 trifluoroacetate EG 00229 EG00229 TFA neuropilin receptor antagonists VEGFA receptors nrp1 Vascular endothelial growth factor SARS-CoV-2 viral cell entry VEGFR Coronavirus 6986, VEGFR, VEGF R

extended description :

Neuropilin 1 (NRP1) receptor antagonist; inhibits VEGFA binding to NRP1

chemical name text :

N2-[[3-[(2,1,3-Benzothiadiazol-4-ylsulfonyl)amino]-2-thienyl]carbonyl]-L-arginine trifluoroacetate

formula :

C 17 H 19 N 7 O 5 S 3 .CF 3 CO 2 H

formula text :

C17H19N7O5S3.CF3CO2H

cas num :

1210945-69-9

2020 USD :

259

2021 USD :

265 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage