6986/10 | Tocris Bioscience 6986/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

6986/10

catalog :

6986/10

quantity :

10 mg

price :

339 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Perez Miller S, Patek M, Moutal A, Duran P, Cabel C, Thorne C, et al. Novel Compounds Targeting Neuropilin Receptor 1 with Potential To Interfere with SARS-CoV-2 Virus Entry. ACS Chem Neurosci. 2021;12:1299-1312 pubmed publisher
Daly J, Simonetti B, Klein K, Chen K, Williamson M, Antón Plágaro C, et al. Neuropilin-1 is a host factor for SARS-CoV-2 infection. Science. 2020;370:861-865 pubmed publisher
Moutal A, Martin L, Boinon L, Gomez K, Ran D, Zhou Y, et al. SARS-CoV-2 spike protein co-opts VEGF-A/neuropilin-1 receptor signaling to induce analgesia. Pain. 2021;162:243-252 pubmed publisher

image

image 1 :

Cat.No. 6986 - EG 00229 trifluoroacetate C17H19N7O5S3.CF3CO2H CAS No. 1210945-69-9

product information

master code :

6986

SKU :

6986/10

product name :

EG 00229 trifluoroacetate

unit size :

10 mg

description :

Neuropilin 1 (NRP1) receptor antagonist; inhibits VEGFA binding to NRP1

target :

VEGF Receptor Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

611.59

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

EG 00229 trifluoroacetate is a neuropilin 1 (NRP1) antagonist; inhibits VEGFA binding to the NRP1 b1 CendR binding pocket. Has no effect on VEGFA binding to VEGFR-1 and VEGFR-2. Reduces VEGFA-induced VEGFR-2 tyrosine phosphorylation in HUVECs. Also attenuates VEGFA-induced HUVEC cell migration and reduces A549 lung carcinoma cell viability in vitro . Inhibits binding of CendR motif in S1 protein of SARS-CoV-2 to NRP1, and reduces efficiency of SARS-CoV-2 infection in Caco-2 cells.

top caption :

Neuropilin 1 (NRP1) receptor antagonist; inhibits VEGFA binding to NRP1

extended description :

Neuropilin 1 (NRP1) receptor antagonist; inhibits VEGFA binding to NRP1

chemical name text :

N2-[[3-[(2,1,3-Benzothiadiazol-4-ylsulfonyl)amino]-2-thienyl]carbonyl]-L-arginine trifluoroacetate

formula :

C17H19N7O5S3.CF3CO2H

formula text :

C17H19N7O5S3.CF3CO2H

cas num :

1210945-69-9

USD :

339 USD

product details :

Neuropilin 1 (NRP1) receptor antagonist; inhibits VEGFA binding to NRP1

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage