6984/2 | Tocris Bioscience 6984/2 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

6984/2

catalog :

6984/2

quantity :

2 mg

price :

179 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

KIN001-266 CAS No. 915363-56-3 Tpl2 inhibitor

product information

master code :

6984

SKU :

6984/2

product name :

KIN001-266

unit size :

2 mg

description :

Potent and selective Tpl2 (MAP3K8) inhibitor

target :

MAP3K8/Tpl2/COT

category :

Small Molecules

purity :

98%

observed molecular weight :

539.44

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

KIN001-266 is a potent and selective Tpl2 (Cot; MAP3K8) inhibitor (IC50 = 1.6 nM). It exhibits 6875-fold selectivity over EGFR. In vivo , it inhibits TNF- production in a LPS-stimulated rat inflammation model. KIN001-266 is orally bioavailable.

top caption :

Potent and selective Tpl2 (MAP3K8) inhibitor

extended description :

Potent and selective Tpl2 (MAP3K8) inhibitor

chemical name text :

8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-(1-ethyl-4-piperidinyl)-1H-1,2,3-triazol-4-yl]methyl]amino]-3-quinolinecarbonitrile

formula :

C26H25Cl2FN8

formula text :

C26H25Cl2FN8

cas num :

915363-56-3

USD :

179 USD

product details :

Potent and selective Tpl2 (MAP3K8) inhibitor

alt names :

Cachetin, Cancer Osaka thyroid oncogene, c-COT, COT, cot (cancer Osaka thyroid) oncogene, COTMEKK8, DIF, EC 2.7.11.25, EST, ESTF, ESTFLJ10486, Ewing sarcoma transformant, MAP3K8, mitogen-activated protein kinase kinase kinase 8, Proto-oncogene c-Cot, proto-oncogene serine/threoine protein kinase, Serine/threonine-protein kinase cot, TNF, TNFA, TNF-A, TNFalpha, TNFG1F, TNFSF1A, TNFSF2, Tpl-2, TPL2, Tumor progression locus 2, tumor progression locus-2

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage