BAY 87-2243 | Tocris Bioscience 6980 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

BAY 87-2243

catalog :

6980

quantity :

25 mg

price :

269 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Ellinghaus P, Heisler I, Unterschemmann K, Haerter M, Beck H, Greschat S, et al. BAY 87-2243, a highly potent and selective inhibitor of hypoxia-induced gene activation has antitumor activities by inhibition of mitochondrial complex I. Cancer Med. 2013;2:611-24 pubmed publisher

product information

brand :

Tocris

master code :

6980

SKU :

6980/25

product name :

BAY 87-2243

description :

Mitochondrial complex I inhibitor

target :

Oxidative Phosphorylation Inhibitors

category :

Small Molecules

unit size :

25 mg

purity :

98%

observed molecular weight :

525.54

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Mitochondrial complex I inhibitor. Exhibits no effect on mitochondrial complex III. Induces mitochondrial permeability transition pore (mPTP) opening, stimulates autophagosome formation and mitophagy, and increases ROS levels. Activates necroptotic and ferroptotic cell death. Also inhibits hypoxia-induced gene activation. Induces cell death in melanoma cell lines in vitro and exhibits antitumor activity in a mouse NSCLC xenograft model in vivo .

catalog number base :

6980

product keywords :

BAY87-2243 Hypoxia inducible factor HIF 1alpha alfa mitochondrial complex I inhibitors inhibits Oxidative Phosphorylation 6980,

extended description :

Mitochondrial complex I inhibitor

chemical name text :

1-Cyclopropyl-4-[4-[[5-methyl-3-[3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]-1H-pyrazol-1-yl]methyl]-2-pyridinyl]piperazine

formula :

C 26 H 26 F 3 N 7 O 2

formula text :

C26H26F3N7O2

cas num :

1227158-85-1

2020 USD :

269

2021 USD :

269 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage