BAY 87-2243 | Tocris Bioscience 6980/5 product information

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product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

BAY 87-2243

catalog :

6980/5

quantity :

5 mg (also 25 mg)

price :

86 USD

citations: 2

Reference
Silwal P, Kim J, Jeon S, Lee J, Kim Y, Kim Y, et al. Mitofusin-2 boosts innate immunity through the maintenance of aerobic glycolysis and activation of xenophagy in mice. Commun Biol. 2021;4:548 pubmed publisher
Ellinghaus P, Heisler I, Unterschemmann K, Haerter M, Beck H, Greschat S, et al. BAY 87-2243, a highly potent and selective inhibitor of hypoxia-induced gene activation has antitumor activities by inhibition of mitochondrial complex I. Cancer Med. 2013;2:611-24 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

6980

SKU :

6980/5

product name :

BAY 87-2243

Description :

Mitochondrial complex I inhibitor

target :

Oxidative Phosphorylation Inhibitors

category :

Small Molecules

unit size :

5 mg (also 25 mg)

purity :

98%

observed molecular weight :

525.54

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

BAY 87-2243 is a mitochondrial complex I inhibitor. Exhibits no effect on mitochondrial complex III. Induces mitochondrial permeability transition pore (mPTP) opening, stimulates autophagosome formation and mitophagy, and increases ROS levels. Activates necroptotic and ferroptotic cell death. Also inhibits hypoxia-induced gene activation. Induces cell death in melanoma cell lines in vitro and exhibits antitumor activity in a mouse NSCLC xenograft model in vivo .

extended description :

Mitochondrial complex I inhibitor

chemical name text :

1-Cyclopropyl-4-[4-[[5-methyl-3-[3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]-1H-pyrazol-1-yl]methyl]-2-pyridinyl]piperazine

formula :

C 26 H 26 F 3 N 7 O 2

formula text :

C26H26F3N7O2

cas num :

1227158-85-1

USD :

86 USD

product details :

Mitochondrial complex I inhibitor

storage :

Store at -20°C