AZD 5363 | Tocris Bioscience 6978 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AZD 5363

catalog :

6978

quantity :

25 mg

price :

545 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

6978

SKU :

6978/25

product name :

AZD 5363

description :

Potent pan-AKT inhibitor

target :

Akt (Protein Kinase B) Inhibitors

category :

Small Molecules

unit size :

25 mg

purity :

98%

observed molecular weight :

428.92

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent pan-AKT inhibitor (IC50 values are 3, 7 and 7 nM for AKt 1, 2 and 3, respectively). Also inhibits P70S6K, PKA, ROCK2 and ROCK1 (IC50 values are 6, 7, 60 and 470 nM, respectively). Inhibits growth of tumor cell lines in vitro , particularly breast, endometrial, gastric, hematologic and prostate cancers. Inhibits growth of human tumor xenografts in mice. Enhances in vivo antitumor effects of Docetaxel (Cat. No. 4056) and Lapatinib (Cat. No. 6811). Orally bioavailable.

catalog number base :

6978

product keywords :

AZD5363 pan AKT inhibitors inhibits potent orally bioavailable protein kinase B PKB Capivasertib Akt (Protein Kinase B) 6978,

extended description :

Potent pan-AKT inhibitor

chemical name text :

4-Amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinecarboxamide

formula :

C 21 H 25 ClN 6 O 2

formula text :

C21H25ClN6O2

cas num :

1143532-39-1

2020 USD :

545

2021 USD :

545 USD

alt names :

Capivasertib

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage