JNJ 10198409 | Tocris Bioscience 6976/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

JNJ 10198409

catalog :

6976/10

quantity :

10 mg (also 50 mg)

price :

252 USD

more info or order :

Tocris Bioscience product webpage

citations: 8

Reference
He D, Lasek A. Anaplastic Lymphoma Kinase Regulates Internalization of the Dopamine D2 Receptor. Mol Pharmacol. 2020;97:123-131 pubmed publisher
Okujeni S, Egert U. Self-organization of modular network architecture by activity-dependent neuronal migration and outgrowth. elife. 2019;8: pubmed publisher
Tam J, Cobb M, Seah C, Pasternak S. Tyrosine Binding Protein Sites Regulate the Intracellular Trafficking and Processing of Amyloid Precursor Protein through a Novel Lysosome-Directed Pathway. PLoS ONE. 2016;11:e0161445 pubmed publisher
Lever R, Hussain A, Sun B, Sage S, Harper A. Conventional protein kinase C isoforms differentially regulate ADP- and thrombin-evoked CaÂ²âº signalling in human platelets. Cell Calcium. 2015;58:577-88 pubmed publisher
Asokan S, Johnson H, Rahman A, King S, Rotty J, Lebedeva I, et al. Mesenchymal chemotaxis requires selective inactivation of myosin II at the leading edge via a noncanonical PLCÎ³/PKCÎ± pathway. Dev Cell. 2014;31:747-60 pubmed publisher
Gan H, Wang G, Hao Q, Wang Q, Tang H. Protein kinase D promotes airway epithelial barrier dysfunction and permeability through down-regulation of claudin-1. J Biol Chem. 2013;288:37343-54 pubmed publisher
Case N, Thomas J, Sen B, Styner M, Xie Z, Galior K, et al. Mechanical regulation of glycogen synthase kinase 3? (GSK3?) in mesenchymal stem cells is dependent on Akt protein serine 473 phosphorylation via mTORC2 protein. J Biol Chem. 2011;286:39450-6 pubmed publisher
Metzger F, Kapfhammer J. Protein kinase C activity modulates dendritic differentiation of rat Purkinje cells in cerebellar slice cultures. Eur J Neurosci. 2000;12:1993-2005 pubmed

image

image 1 :

Cat.No. 6976 - JNJ 10198409 C18H16FN3O2 CAS No. 627518-40-5

product information

brand :

Tocris

master code :

6976

SKU :

6976/10

product name :

JNJ 10198409

unit size :

10 mg (also 50 mg)

seo description :

Potent PDGFR and PDGFR inhibitor; also inhibits c-Abl, Lck, c-Src and Fyn kinases

target :

PDGF Receptor Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

325.34

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

JNJ 10198409 is a potent platelet-derived growth factor receptor (PDGFR) inhibitor (IC50 values are 4.2 and 45 nM for PDGFR and PDGFR , respectively). Also inhibits c-Abl, Lck, c-Src and Fyn kinases (IC50 values are 22, 100, 185 and 378 nM respectively). Displays antiproliferative activity in multiple tumor cell lines. Accelerates down regulation of fibroblast genes in transdifferentiation of human fibroblasts into functional cardiomyocytes, within 9C cocktail. . For more information about how JNJ 10198409 may be used, see our protocol: Converting Fibroblasts into Cardiomyocytes (9C Cocktail)

top caption :

Potent PDGFR and PDGFR inhibitor; also inhibits c-Abl, Lck, c-Src and Fyn kinases

extended description :

Potent PDGFR and PDGFR inhibitor; also inhibits c-Abl, Lck, c-Src and Fyn kinases

chemical name text :

N-(3-Fluorophenyl)-1,4-dihydro-6,7-dimethoxyindeno[1,2-c]pyrazol-3-amine

formula :

C18H16FN3O2

formula text :

C18H16FN3O2

cas num :

627518-40-5

USD :

252 USD

product details :

Potent PDGFR and PDGFR inhibitor; also inhibits c-Abl, Lck, c-Src and Fyn kinases

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage