aTAG 4531 | Tocris Bioscience 6971/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

aTAG 4531

catalog :

6971/5

quantity :

5 mg

price :

483 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 6971 - aTAG 4531 C46H39F2N9O7

product information

brand :

Tocris

master code :

6971

SKU :

6971/5

product name :

aTAG 4531

unit size :

5 mg

seo description :

Degrader of MTH1 fusion proteins for use within the aTAG system

target :

TAG Degradation Platforms

category :

Small Molecules

purity :

98%

observed molecular weight :

867.85

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

aTAG 4531 is a degrader of MTH1 fusion proteins for use within the aTAG system. Comprises a ligand selective for MTH1, a linker and the cereblon-binding ligand Thalidomide (Cat. No. 0652). Induces highly potent and selective degradation of fusion proteins after a 4 h incubation (DC50 = 0.34 nM; Dmax = 93.14%). Cell-permeable. Suitable for in vitro and in vivo applications. . Mouse DMPK properties are provided in the supplementary file (see below). . MTH1 can be expressed as a fusion with a target protein of interest using genome engineering techniques via CRISPR-mediated locus-specific knock-in. See protocol for more information.

top caption :

Degrader of MTH1 fusion proteins for use within the aTAG system

extended description :

Degrader of MTH1 fusion proteins for use within the aTAG system

chemical name text :

N-Cyclopropyl-6-(4-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)methyl)-1H-1,2,3-triazol-1-yl)butyl)carbamoyl)-3-fluorophenyl)-7-fluoro-4-(phenylamino)quinoline-3-carboxamide

formula :

C46H39F2N9O7

formula text :

C46H39F2N9O7

cas num :

2412985-00-1

USD :

483 USD

product details :

Degrader of MTH1 fusion proteins for use within the aTAG system

alt names :

CFT 4531

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage