JBJ-03-142-02 | Tocris Bioscience 6962/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

JBJ-03-142-02

catalog :

6962/10

quantity :

10 mg

price :

256 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 6962 - JBJ-03-142-02 C25H22FN7O3 CAS No. 2068806-31-3

product information

brand :

Tocris

master code :

6962

SKU :

6962/10

product name :

JBJ-03-142-02

unit size :

10 mg

seo description :

Highly potent EGFR and ErbB2 inhibitor; inhibts wild type and mutated receptors

target :

EGF Receptor Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

487.5

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

JBJ-03-142-02 is a highly potent epidermal growth factor receptor (EGFR) and ErbB2 (human epidermal growth factor receptor; HER2) inhibitor. Inhibits wild type and tumorgenic mutated receptors (exon 20 insertion; Ex20Ins). Antiproliferative in vitro (IC50 values are 7.6, 30 - 95, 3.8 and 19 - 31 nM for Ba/F3 cells expressing wild type EGFR, EGFR with Ex20Ins mutation, wild type HER2 and HER2 with Ex20Ins mutation, respectively). Also inhibits other common EGFR mutants. Antiproliferative in patient-derived lung cancer cell lines.

top caption :

Highly potent EGFR and ErbB2 inhibitor; inhibts wild type and mutated receptors

extended description :

Highly potent EGFR and ErbB2 inhibitor; inhibts wild type and mutated receptors

chemical name text :

(4-Fluorophenyl)methyl N-[2-[(1-methyl-1H-pyrazol-4-yl)amino]-4-pyrimidinyl]-N-[3-[(1-oxo-2-propen-1-yl)amino]phenyl]carbamate

formula :

C25H22FN7O3

formula text :

C25H22FN7O3

cas num :

2068806-31-3

USD :

256 USD

product details :

Highly potent EGFR and ErbB2 inhibitor; inhibts wild type and mutated receptors

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage