ABT 199 | Tocris Bioscience 6960/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

ABT 199

catalog :

6960/10

quantity :

10 mg (also 50 mg)

price :

94 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Gr xf8 nnings xe6 ter I, Reikvam H, Aaseb xf8 E, Bartaula Brevik S, Tvedt T, Bruserud x, et al. Targeting Cellular Metabolism in Acute Myeloid Leukemia and The Role of Patient Heterogeneity. Cells. 2020;9: pubmed publisher

product information

brand :

Tocris

master code :

6960

SKU :

6960/10

product name :

ABT 199

unit size :

10 mg (also 50 mg)

seo description :

Selective, high affinity Bcl-2 inhibitor; orally bioavailable

target :

Bcl-2 Family Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

868.45

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

ABT 199 is a selective, high affinity Bcl-2 inhibitor (Ki 0.010 nM). Exhibits 4800-fold selectivity for Bcl-2 over Bcl-xL and Bcl-w, and displays no measurable activity at Mcl-1 (Ki 444 nM). Potently induces apoptosis in FL5.12-BCL-2 cells (EC50 = 261 nM) and reduces tumor burden in chronic lymphocytic leukemia (CLL) primary samples (EC50 = 3 nM). Shows reduced toxicity to platelets compared to similar compounds. Enhances efficacy of clinically relevant chemotherapy and immunotherapy drugs. Orally bioavailable. Exhibits binding to SARS-CoV-2 3C-like protease (3CLpro) active site in a virtual screen. ABT 199 reverses oxidative phosphorylation in acute myeloid leukemia cells (AML), in vitro and in vivo .

top caption :

Selective, high affinity Bcl-2 inhibitor; orally bioavailable

extended description :

Selective, high affinity Bcl-2 inhibitor; orally bioavailable

chemical name text :

4-[4-[[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[3-nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]phenyl]sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide

formula :

C45H50ClN7O7S

formula text :

C45H50ClN7O7S

cas num :

1257044-40-8

USD :

94 USD

product details :

Selective, high affinity Bcl-2 inhibitor; orally bioavailable

alt names :

Venetoclax,GDC-0199

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage