Galunisertib | Tocris Bioscience 6956 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Galunisertib

catalog :

6956

quantity :

25 mg

price :

426 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

6956

SKU :

6956/25

product name :

Galunisertib

description :

ALK4 and ALK5 (TGF RI) inhibitor

target :

TGF-beta Receptor Inhibitors

category :

Small Molecules

unit size :

25 mg

purity :

98%

observed molecular weight :

369.43

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

ALK4 and ALK5 (TGF RI) inhibitor (IC50 values are 77.7 and 172 nM, respectively). Also inhibits a range of other kinases with submicromolar IC50s including MINK, TGF RII, ALK6 and ACVR2B. Inhibits TGF -induced SMAD phosphorylation in cancer cell lines in vitro and in vivo . Also reverses TGF -mediated suppression of T cell proliferation. Prevents TGF -mediated EMT and cell migration in vitro and exhibits antitumor efficacy in vivo . Used as component of growth media for urothelial organoids. Orally bioavailable.

catalog number base :

6956

product keywords :

TGFbetaRI TGFBRI inhibitors inhibits ALK5 ALK4 smad phosphorylation anticancer orally bioavailable growth media organoids LY 2157299 TGF-beta Receptors Organoids 6956,

extended description :

ALK4 and ALK5 (TGF RI) inhibitor

chemical name text :

4-[5,6-Dihydro-2-(6-methyl-2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]-6-quinolinecarboxamide

formula :

C 22 H 19 N 5 O

formula text :

C22H19N5O

cas num :

700874-72-2

2020 USD :

409

2021 USD :

426 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage