Galunisertib | Tocris Bioscience 6956/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Galunisertib

catalog :

6956/5

quantity :

5 mg (also 25 mg)

price :

141 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Natani S, Sruthi K, Asha S, Khilar P, Lakshmi P, Ummanni R. Activation of TGF-β - SMAD2 signaling by IL-6 drives neuroendocrine differentiation of prostate cancer through p38MAPK. Cell Signal. 2022;91:110240 pubmed publisher
Ven xf8 M, Reschke C, Morris G, Connolly N, Su J, Yan Y, et al. A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy. Proc Natl Acad Sci U S A. 2020;117:15977-15988 pubmed publisher

image

image 1 :

Cat.No. 6956 - Galunisertib C22H19N5O CAS No. 700874-72-2

product information

brand :

Tocris

master code :

6956

SKU :

6956/5

product name :

Galunisertib

unit size :

5 mg (also 25 mg)

seo description :

ALK4 and ALK5 (TGF RI) inhibitor

target :

TGF-beta Receptor Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

369.43

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Galunisertib is an ALK4 and ALK5 (TGF RI) inhibitor (IC50 values are 77.7 and 172 nM, respectively). Also inhibits a range of other kinases with submicromolar IC50s including MINK, TGF RII, ALK6 and ACVR2B. Inhibits TGF -induced SMAD phosphorylation in cancer cell lines in vitro and in vivo . Also reverses TGF -mediated suppression of T cell proliferation. Prevents TGF -mediated EMT and cell migration in vitro and exhibits antitumor efficacy in vivo . Used as component of growth media for urothelial organoids. Orally bioavailable.

top caption :

ALK4 and ALK5 (TGF RI) inhibitor

extended description :

ALK4 and ALK5 (TGF RI) inhibitor

chemical name text :

4-[5,6-Dihydro-2-(6-methyl-2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]-6-quinolinecarboxamide

formula :

C22H19N5O

formula text :

C22H19N5O

cas num :

700874-72-2

USD :

141 USD

product details :

ALK4 and ALK5 (TGF RI) inhibitor

alt names :

LY 2157299

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage