CRBN-6-5-5-VHL | Tocris Bioscience 6948 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

CRBN-6-5-5-VHL

catalog :

6948

quantity :

5 mg

price :

363 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

6948

SKU :

6948/5

product name :

CRBN-6-5-5-VHL

description :

Potent and selective cereblon degrader; cell-permeable

target :

Active Degraders

category :

Small Molecules

unit size :

5 mg

purity :

96%

observed molecular weight :

972.21

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective cereblon degrader (DC50 = 1.5 nM). Induces complete degradation of cereblon in MM1S cells. Comprises a cereblon E3 ligase ligand joined by a linker to a ligand for the E3 ligase VHL. Cell-permeable.

catalog number base :

6948

product keywords :

PROTACs proteolysis targeting chimeras active Degraders degrades VHL von Hippel Lindau Cereblon CRBN PROTAC targeted protein degradation tpd Active Degraders Ubiquitin E3 Ligases 6948, target protein knockdown, PROTAC, SNIPER

extended description :

Potent and selective cereblon degrader; cell-permeable

chemical name text :

(2S,4R)-1-((2S)-2-(5-((5-((6-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexyl)oxy)pentyl)oxy)pentanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

formula :

C 51 H 69 N 7 O 10 S

formula text :

C51H69N7O10S

cas num :

2362575-45-7

2020 USD :

349

2021 USD :

363 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage