dBET6 | Tocris Bioscience 6945 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

dBET6

catalog :

6945

quantity :

5 mg

price :

219 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 6945 - dBET6 C42H45ClN8O7S CAS No. 1950634-92-0

product information

brand :

Tocris

master code :

6945

SKU :

6945/5

product name :

dBET6

description :

Potent and selective (+)-JQ1 based PROTAC targeting BET bromodomains, active in vivo

target :

Active Degraders

category :

Small Molecules

unit size :

5 mg

purity :

98%

observed molecular weight :

841.38

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective degrader of BET bromodomains (IC50 = ~10 nM). PROTAC comprising BET antagonist (+)-JQ1 (Cat.No. 4499) conjugated to a cereblon E3 ubiquitin ligase ligand. Exhibits antitumor activity against T cell acute lymphoblastic leukemia (T-ALL) lines through BRD4 degradation. Induces apoptosis. Reduces leukemic burden in a mouse model of T-ALL. Cell permeable. . PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

catalog number base :

6945

product keywords :

Potent selective active degraders degrades BET bromodomains BRD4 Proteolysis Targeting Chimera PROTAC cereblon E3 ubiquitin ligase bromodomain BRD4 degradation JQ1 cell permeable active in vivo tpd Active Degraders Bromodomains Ubiquitin E3 Ligases 6945, target protein knockdown, PROTAC, SNIPER

extended description :

Potent and selective (+)-JQ1 based PROTAC targeting BET bromodomains, active in vivo

chemical name text :

(6S)-4-(4-Chlorophenyl)-N-[8-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]octyl]-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide

formula :

C 42 H 45 ClN 8 O 7 S

formula text :

C42H45ClN8O7S

cas num :

1950634-92-0

2020 USD :

219

2021 USD :

219 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage